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"A haplotype map of the human genome,"
by The International HapMap Consortium (D. Altshuler, et al.),
Nature, 437(7063): 1299-1320, 27 October 2005.
[Authors' affiliations: 63 institutions
worldwide]
Abstract: "Inherited genetic variation
has a critical but as yet largely uncharacterized role in human disease.
Here we report a public database of common variation in the human genome:
more than one million single nucleotide polymorphisms (SNPs) for which
accurate and complete genotypes have been obtained in 269 DNA samples from
four populations, including ten 500-kilobase regions in which essentially
all information about common DNA variation has been extracted. These data
document the generality of recombination hotspots, a block-like structure of
linkage disequilibrium and low haplotype diversity, leading to substantial
correlations of SNPs with many of their neighbours. We show how the HapMap
resource can guide the design and analysis of genetic association studies,
shed light on structural variation and recombination, and identify loci that
may have been subject to natural selection during human evolution."
This 2005 report from Nature was
cited 59 times in current journal articles indexed by Thomson
Scientific during March-April 2007. For what is now the ninth bimonthly
period in a row, this report scores as the most-cited biology paper
published in the last two years, aside from reviews. Prior to the most
recent two-month count, citations to the paper have accrued as follows:
March-April 2007: 84 citations
February-March 2007: 59
January-February 2007: 95
November-December 2006: 75
September-October 2006: 94
July-August 2006: 57
May-June 2006: 74
March-April 2006: 55
January-February 2006: 22
November-December 2005: 7
Total citations to date: 691
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