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"A haplotype map of the human
genome," by The International
HapMap Consortium (D. Altshuler, et al.), Nature, 437(7063):
1299-1320, 27 October 2005.
[Authors' affiliations: 63 institutions
worldwide]
Abstract:
"Inherited genetic variation has a critical but as yet largely
uncharacterized role in human disease. Here we report a public database of
common variation in the human genome: more than one million single nucleotide
polymorphisms (SNPs) for which accurate and complete genotypes have been
obtained in 269 DNA samples from four populations, including ten 500-kilobase
regions in which essentially all information about common DNA variation has
been extracted. These data document the generality of recombination hotspots,
a block-like structure of linkage disequilibrium and low haplotype diversity,
leading to substantial correlations of SNPs with many of their neighbours. We
show how the HapMap resource can guide the design and analysis of genetic
association studies, shed light on structural variation and recombination, and
identify loci that may have been subject to natural selection during human
evolution."
This 2005 report from Nature was cited
74 times in current journal articles indexed by Thomson
Scientific during May-June 2006. The report thereby emerges, for the second
consecutive bimonthly period, as the most-cited biology paper published in the
last two years, aside from reviews. Prior to the most recent two-month count,
citations to the paper have accrued as follows:
March-April 2006: 55 citations
January-February 2006: 22
November-December 2005: 7
Total citations to date: 158
SOURCE: Hot
Papers Database (Included with a subscription to the print newsletter Science
Watch®, available from the
Research Services Group. Packaged on a CD that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
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six times a year. The CD also includes an electronic version of the Science
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