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"Regulatory T cell lineage
specification by the forkhead transcription factor FoxP3,"
by Jason D. Fontenot, Jeffrey P. Rasmussen, Luke M. Williams, James L. Dooley,
Andrew G. Farr, and Alexander Y. Rudensky, Immunity, 22(3): 329-41,
March 2005.
[Authors' affiliations: Howard Hughes Medical
Institute, and University of Washington, Seattle]
Abstract:
"Regulatory T cell-mediated dominant tolerance has been demonstrated to
play an important role in the prevention of autoimmunity. Here, we present
data arguing that the forkhead transcription factor Foxp3 acts as the
regulatory T cell lineage specification factor and mediator of the genetic
mechanism of dominant tolerance. We show that expression of Foxp3 is highly
restricted to the subset alpha/beta of T cells and, irrespective of CD25
expression, correlates with suppressor activity. Induction of Foxp3 expression
in nonregulatory T cells does not occur during pathogen-driven immune
responses, and Foxp3 deficiency does not impact the functional responses of
nonregulatory T cells. Furthermore, T cell-specific ablation of Foxp3 is
sufficient to induce the identical early onset lymphoproliferative syndrome
observed in Foxp3-deficient mice. Analysis of Foxp3 expression during thymic
development suggests that this mechanism is not hard-wired but is dependent on
TCR/MHC ligand interactions."
This 2005 report from Immunity was
cited 40 times in current journal articles indexed by Thomson
Scientific during July-August 2006. Only one other biology paper published in
the last two years, aside from reviews, attracted a greater number of
citations during that two-month period. Prior to the most recent bimonthly
count, citations to the paper have accrued as follows:
May-June 2006: 23 citations
March-April 2006: 22
January-February 2006: 20
November-December 2005: 23
September-October 2005: 12
July-August 2005: 4
May-June 2005: 2
March-April 2005: 1
Total citations to date: 147
SOURCE: Hot
Papers Database (Included with a subscription to the print newsletter Science
Watch®, available from the
Research Services Group. Packaged on a CD that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
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issue in HTML format, for personal desktop access.
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