|
"EGFR mutations in lung cancer:
Correlation with clinical response to gefitinib therapy,"
by J. Guillermo Paez and 16 others, Science, 304(5676): 1497-1500, 4
June 2004.
[Authors' affiliations: 7 U.S. and Japanese
institutions]
Abstract:
"Receptor tyrosine kinase genes were sequenced in non-small cell lung
cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene
EGFR were found in 15 of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment
with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently
in Japan. EGFR mutations were foundin additional lung cancer samples from U.S.
patients who responded to gefitinib therapy and in a lung adenocarcinoma cell
line that was hypersensitive to growth inhibition by gefitinib, but not in
gefitinib-insensitive tumors or cell lines. These results suggest that EGFR
mutations may predict sensitivity to gefitinib."
This 2004 report from Science was
cited 86 times in current journal articles indexed by Thomson
Scientific during July-August 2005. Repeating its ranking in the previous
two-month tally (based on May-June citations), this report once again scores
as the second-most-cited medicine paper published in the last two years, aside
from reviews. Prior to the most recent bimonthly count, citations to the paper
have accrued as follows:
May-June 2005: 91 citations
March-April 2005: 66
January-February 2005: 49
November-December 2004: 36
September-October 2004: 27
July-August 2004: 8
May-June 2004: 1
Total citations to date: 364
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access.)
View the past and present top 10
scientists and/or top
3 Hot Papers in Clinical Medicine.
- Analysis
of
Clinical
Medicine.
- Assorted features pertaining to Clinical
Medicine
from all of the ISI Essential Science Indicators Web based
product editorials.
Features include interviews, essays, comments, profiles, and
rankings of the top- performing scientists, institutions,
countries, journals, papers, and fields.
|
|
cites
:
