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"SWISS-MODEL: an automated protein
homology-modeling server," by
Torsten Schwede, Jurgen Kopp,
Nicolas Guex, and Manuel C. Peitsch, Nucleic Acids Research, 31(13):
3381-5, 1 July 2003.
[University of Basel, Switzerland; Swiss
Institute of Bioinformatics, Basel; GlaxoSmithKline, Research Triangle
Park, NC; Novartis AG, Basel, Switzerland]
Abstract: "SWISS-MODEL (http://swissmodel.expasy.org)
is a server for automated comparative modeling of
three-dimensional (3D) protein structures. It pioneered the field of automated
modeling starting in 1993 and is the
most widely-used free web-based automated modeling facility today. In 2002 the
server computed 120 000 user
requests for 3D protein models. SWISS-MODEL provides several levels of user
interaction through its World Wide
Web interface: in the 'first approach mode' only an amino acid sequence of a
protein is submitted to build a 3D model. Template selection, alignment and
model building are done completely automated by the server. In the 'alignment
mode', the modeling process is based on a user-defined target-template
alignment. Complex modeling tasks can be handled with the 'project mode' using
DeepView (Swiss-PdbViewer), an integrated sequence-to-structure workbench. All
models are sent back via email with a detailed modeling report. WhatCheck
analyses and ANOLEA evaluations are provided optionally. The reliability of
SWISS-MODEL is continuously evaluated in the EVA-CM project. The SWISS-MODEL
server is under constant development to improve the successful implementation
of expert knowledge into an easy-to-use server."
This 2003 report from Nucleic Acids
Research was cited 35 times in newly published journal
articles indexed by Thomson Scientific during November-December 2004. Thanks
to its latest bimonthly total, this is currently the second-most-cited biology
paper published in the last two years (not counting reviews). Prior to the
most recent bimonthly count, citations to the paper have accrued as follows:
September-October 2004: 32 citations
July-August 2004: 28
May-June 2004: 14
March-April 2004: 12
January-February 2004: 15
November-December 2003: 3
Total citations to date: 139
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access.)
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