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"EGFR mutations in lung cancer:
Correlation with clinical response to gefitinib therapy,"
by J. Guillermo Paez
and 16 others, Science, 304(5676): 1497-1500, 4 June 2004.
[Authors' affiliations: 7 U.S. and Japanese
institutions]
Abstract:
"Receptor tyrosine kinase genes were sequenced in non-small cell lung
cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal
growth factor receptor gene EGFR were found in 15 of 58 unselected tumors from
Japan and 1 of 61 from the United States. Treatment with the EGFR kinase
inhibitor gefitinib (Iressa) causes tumor regression in some patients with
NSCLC, more frequently in Japan. EGFR mutations were found in additional lung
cancer samples from U.S. patients who responded to gefitinib therapy and in a
lung adenocarcinoma cell line that was hypersensitive to growth inhibition by
gefitinib, but not in gefitinib-insensitive tumors or cell lines. These
results suggest that EGFR mutations may predict sensitivity to gefitinib."
This 2004 report from Science was
cited 82 times in current journal articles indexed by Thomson
Scientific during
March-April 2005. Only one other medicine paper published in the last two
years, aside from reviews, garnered
a greater number of citations during that two-month period. Prior to the most
recent bimonthly count, citations to
the paper have accrued as follows:
January-February 2005: 51 citations
November-December 2004: 22
September-October 2004: 29
July-August 2004: 4
May-June 2004: 1
Total citations to date: 189
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access.)
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