|
"Protein conformational dynamics
probed by single-molecule electron transfer,"
by Haw Yang and 7 others,
Science, 302(5643): 262-6, 10 October 2003.
[Authors' affiliations: Harvard University,
Cambridge, MA; Washington State University, Pullman; University of California,
Berkeley]
Abstract:
"Electron transfer is used as a probe for angstrom-scale structural
changes in single protein molecules. In a flavin reductase, the fluorescence
of flavin is quenched by a nearby tyrosine residue by means of photo-induced
electron transfer. By probing the fluorescence lifetime of the single flavin
on a photon-by-photon basis, we were able to observe the variation of flavin-tyrosine
distance over time. We could then determine the potential of mean force
between the flavin and the tyrosine, and a correlation analysis revealed
conformational fluctuation at multiple time scales spanning from hundreds of
microseconds to seconds. This phenomenon suggests the existence of multiple
interconverting conformers related to the fluctuating catalytic
reactivity."
This 2003 report in Science was cited 16
times in current journal articles indexed by Thomson Scientific during
March-April 2005. Only two other papers in chemistry published in the last two
years, aside from reviews, collected a greater number of citations during that
two-month period. Prior to the most recent bimonthly count, citations to the
paper have accrued as follows:
January-February 2005: 8 citations
November-December 2004: 6
September-October 2004: 8
July-August 2004: 5
May-June 2004: 2
March-April 2004: 1
November-December 2003: 1
September-October 2003: 1
Total citations to date: 48
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access
Previous Page | Return to SCI-BYTES
Main Menu
| Return to 2005 Menu
If you came from the Thomson Scientific Web site, click
here to return
|
cites
:
