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"In vivo imaging of quantum dots
encapsulated in phospholipid micelles,"
by Benoit Dubertret and 5 others,
Science, 298(5599): 1759-62, 29 November 2002.
[Authors' affiliations: Rockefeller
University, New York, NY; NEC Research Institute, Princeton, NJ; University
of Minnesota, MN]
Abstract: "Fluorescent
semiconductor nanocrystals (quantum
dots) have the potential to revolutionize biological
imaging, but their use has been limited by difficulties in obtaining
nanocrystals that are biocompatible. To address
this problem, we encapsulated individual nanocrystals in phospholipid
block-copolymer micelles and demonstrated
both in vitro and in vivo imaging. When conjugated to DNA, the nanocrystal-micelles
acted as in vitro fluorescent
probes to hybridize to specific complementary sequences. Moreover, when
injected into Xenopus embryos, the
nanocrystal-micelles were stable, nontoxic (<5 x 10(9) nanocrystals per
cell), cell autonomous, and slow to photobleach. Nanocrystal fluorescence
could be followed to the tadpole stage, allowing lineage-tracing experiments
in embryogenesis."
This 2002 report from Science was
cited 20 times in current journal articles indexed by Thomson
Scientific
during September-October 2004. Its citation total during that two-month period
made this the second most-cited
of any paper categorized as chemistry by the Hot Papers database and published
in the last two years, aside from
reviews. Prior to the most recent bimonthly count, citations to the paper have
accrued as follows:
July-August 2004: 12 citations
May-June 2004: 9
March-April 2004: 9
January-February 2004: 14
November-December 2003: 10
September-October 2003: 14
July-August 2003: 6
May-June 2003: 4
March-April 2003: 4
January-February 2003: 2
Total citations to date: 104
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
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