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"Initial sequencing and analysis of
the human genome," by the
International Human Genome Sequencing Consortium
(Eric
S. Lander and 241 others), Nature, 409(6822):860-921, 15 February
2001.
 :
Read an interview with Eric
S. Lander.
[Authors' affiliations: 20 groups worldwide]
From the introduction: "Here we
report the results of a collaboration involving 20 groups from the United
States, the United Kingdom, Japan, France, Germany and China to produce a
draft sequence of the human genome. The draft genome sequence was generated
from a physical map covering more than 96% of the euchromatic part of the
human genome and, together with additional sequence in public databases, it
covers about 94% of the human genome. The sequence was produced over a
relatively short period, with coverage rising from about 10% to more than 90%
over roughly fifteen months. The sequence data have been made available
without restriction and updated daily throughout the project. The task ahead
is to produce a finished sequence, by closing all gaps and resolving all
ambiguities. Already about one billion bases are in final form and the task of
bringing the vast majority of the sequence to this standard is now
straightforward and should proceed rapidly...."
This 2001 report from Nature,
representing the publicly funded effort to sequence the human genome, was cited
approximately 200 times in current journal articles
indexed in the ISI database during September-October 2002. With its latest
two-month
total, this paper remains by far the most-cited report published in biology in
the last two years; indeed, during the September-October count it was the
most-cited report in all of science, including reviews. As in previous counts,
its only rival for bimonthly citations is the report, published simultaneously
in Science, representing the privately funded human-genome
collaboration. Both papers have now garnered more than 1,300 citations each,
although the Nature paper holds a lead of a few hundred in the
overall tally as of late December 2002.
Total citations as of 12/30/02: 1,716
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access.)
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