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"Crystallography and NMR System: A
new software suite for macromolecular structure determination,"
by Axel T. Brunger and 13 others, Acta Crystallographica Section D:
Biological Crystallography, 54:901-21, 1 September 1998.
[Authors' affiliations: 10 institutions
worldwide]
"Abstract: A new software suite,
called Crystallography & NMR System, (CNS), has been
developed for macromolecular structure determination by X-ray crystallography
or solution nuclear magnetic resonance (NMR) spectroscopy. In contrast to
existing structure-determination programs the architecture of CNS is
highly flexible, allowing for extension to other structure-determination
methods, such as electron microscopy and solid-state NMR spectroscopy. CNS has
a hierarchical structure: a high-level hypertext markup language (HTML) user
interface, task-oriented user input files, module files, a symbolic
structure-determination language (CNS language), and low-level source
code. Each layer is accessible to the user. The novice user may just use the
HTML interface, while the more advanced user may use any of the other layers.
The source code wil be distributed, thus source-code modification is possible.
The CNS language is sufficiently powerful and flexible that many new
algorithms can be easily implemented in the CNS language without changes to
the source code. The CNS language allows the user to perform operations
on data structures, such as structure factors, electron-density maps, and
atomic properties. The power of the CNS language has been demonstrated
by the implementation of a comprehensive set of crystallographic procedures
for phasing, density modification and refinement. User-friendly task-oriented
input files are available for nearly all aspects of macromolecular structure
determination by X-ray crystallography and solution NMR."
This 1998 report from Acta
Crystallographic Section D was cited 103 times in current
journal articles indexed in the ISI database during July-August 2000. On the
basis of bimonthly citations, this paper--as it has for more than a year
now--tops all chemistry papers published in the last two years. In fact,
during July-August this was one of only three papers (including reviews) in
any discipline to be cited more than 100 times. Prior to the most recent
bimonthly count, citations to the paper have accrued as follows:
May-June 2000: 80 citations
March-April 2000: 98
January-February 2000: 67
November-December 1999: 64
September-October 1999: 40
July-August 1999: 31
May-June 1999: 36
March-April 1999: 17
January-February 1999: 23
November-December 1998: 3
September-October 1998: 2
Total citations to date: 564
SOURCE: Hot
Papers Database (Available from the ISI
Research Services Group in a CD-ROM version containing data on
hundreds of highly cited papers published during the last two years.
User interface permits searching by author, organization, journal,
field, and more. Total citations, as well as citations accrued during
successive bimonthly periods, can be assessed and graphed. Database is
combined with subscription to the ISI newsletter Science
Watch®; updated discs containing the
most recent bimonthly data are mailed with each new issue, six times a
year.)
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